Adderall Xr Side Effects

Postmarketing reports: Rhabdomyolysis [Ref]

Adderall Side Effects

Medically reviewed by Drugs.com. Last updated on Nov 1, 2022.

Note: This document contains side effect information about amphetamine / dextroamphetamine. Some dosage forms listed on this page may not apply to the brand name Adderall.

Applies to amphetamine / dextroamphetamine: oral capsule extended release, oral tablet.

Warning

Oral route (Tablet)

Amphetamines have a high potential for abuse and administration for prolonged periods of time may lead to drug dependence. Misuse of amphetamines may cause sudden death and serious cardiovascular adverse reactions.

Oral route (Capsule, Extended Release)

CNS stimulants, including dextroamphetamine/amphetamine extended-release capsules, other amphetamine-containing products, and methylphenidate, have a high potential for abuse and dependence. Assess the risk of abuse prior to prescribing and monitor for signs of abuse and dependence while on therapy.

Serious side effects of Adderall

Along with its needed effects, amphetamine / dextroamphetamine may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor immediately if any of the following side effects occur while taking amphetamine / dextroamphetamine:

More common

  • Bladder pain
  • bloody or cloudy urine
  • difficult, burning, or painful urination
  • fast, pounding, or irregular heartbeat or pulse
  • frequent urge to urinate
  • lower back or side pain

Less common

  • Chills
  • cough
  • diarrhea
  • fever
  • general feeling of discomfort or illness
  • headache
  • hoarseness
  • joint pain
  • loss of appetite
  • muscle aches and pains
  • nausea
  • runny nose
  • shivering
  • sore throat
  • sweating
  • trouble sleeping
  • unusual tiredness or weakness
  • vomiting

Incidence not known

  • Blistering, peeling, or loosening of the skin
  • chest pain or discomfort
  • confusion
  • dark urine
  • difficulty breathing
  • difficulty with speaking
  • difficulty with swallowing
  • dizziness
  • double vision
  • faintness
  • inability to move the arms, legs, or facial muscles
  • inability to speak
  • itching, skin rash
  • large, hive-like swelling on the face, eyelids, lips, tongue, throat, hands, legs, feet, or genitals
  • loss of bladder control
  • muscle cramps or stiffness
  • muscle spasm or jerking of the arms and legs
  • pain or discomfort in the arms, jaw, back, or neck
  • red skin lesions, often with a purple center
  • red, irritated eyes
  • seeing, hearing, or feeling things that are not there
  • seizures
  • slow speech
  • sores, ulcers, or white spots in the mouth or on the lips
  • sudden loss of consciousness
  • swelling of the feet or lower legs
  • tightness in the chest
  • uncontrolled repeated movements (tics)
  • uncontrolled vocal outbursts
  • unusual tiredness or weakness

Other side effects of Adderall

Some side effects of amphetamine / dextroamphetamine may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects.

Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

More common

  • Anxiety
  • dry mouth
  • lack or loss of strength
  • stomach pain
  • weight loss

Incidence not known

  • Constipation
  • decreased interest in sexual intercourse
  • false or unusual sense of well-being
  • inability to have or keep an erection
  • loss in sexual ability, desire, drive, or performance
  • twitching, twisting, uncontrolled repetitive movements of the tongue, lips, face, arms, or legs
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For Healthcare Professionals

Applies to amphetamine / dextroamphetamine: oral capsule extended release, oral tablet.

Metabolic

Very common (10% or more): Appetite loss (up to 36%), weight loss (up to 10%)

Frequency not reported: Anorexia [Ref]

Gastrointestinal

Very common (10% or more): Dry mouth (up to 35%), abdominal pain (up to 14%)

Common (1% to 10%): Nausea, vomiting, diarrhea, dyspepsia

Frequency not reported: Unpleasant taste, constipation, other GI disturbances [Ref]

Cardiovascular

Very common (10% or more): Transient blood pressure elevations (up to 35%)

Common (1% to 10%): Tachycardia, palpitation

Frequency not reported: Cardiomyopathy, myocardial infarction, Raynaud’s phenomenon [Ref]

Psychiatric

Very common (10% or more): Insomnia (up to 27%), nervousness (up to 13%)

Common (1% to 10%): Emotional lability, agitation, anxiety

Frequency not reported: Psychotic episodes, irritability, euphoria, dysphoria, restlessness, depression, aggression, anger, logorrhea, dermatillomania [Ref]

Nervous system

Very common (10% or more): Headache (up to 26%)

Common (1% to 10%): Somnolence, dizziness, twitching, speech disorder (e.g., stuttering, excessive speech)

Frequency not reported: Overstimulation, paresthesia/formication, dyskinesia, tremor, exacerbation of motor/phonic tics and Tourette’s syndrome [Ref]

Dermatologic

Common (1% to 10%): Photosensitivity reaction, sweating

Endocrine

Common (1% to 10%): Decreased libido, dysmenorrhea, impotence

Frequency not reported: Frequent or prolonged erections [Ref]

Genitourinary

Other

Common (1% to 10%): Fever, infection, accidental injury, asthenia/fatigue, tooth disorder (e.g., teeth clenching, tooth infection)

Frequency not reported: Sudden death, bruxism [Ref]

Respiratory

Hypersensitivity

Frequency not reported: Hypersensitivity reactions (e.g., angioedema, anaphylaxis) [Ref]

Ocular

Frequency not reported: Blurred vision, mydriasis [Ref]

Musculoskeletal

Postmarketing reports: Rhabdomyolysis [Ref]

Frequently asked questions

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  • Can Adderall cause constipation?
  • Is Adzenys XR-ODT the same as Adderall XR?

More about Adderall (amphetamine / dextroamphetamine)

  • Check interactions
  • Compare alternatives
  • Pricing & coupons
  • Reviews (450)
  • Drug images
  • Dosage information
  • Patient tips
  • During pregnancy
  • Generic availability
  • Support group
  • Drug class: CNS stimulants
  • En español

Patient resources

Other brands

Professional resources

Other formulations

Related treatment guides

References

1. “Product Information. Adderall (amphetamine-dextroamphetamine).” Shire Richwood Pharmaceutical Company Inc (2001):

2. “Product Information. Adderall XR (amphetamine-dextroamphetamine).” Shire Richwood Pharmaceutical Company Inc (2001):

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

Some side effects may not be reported. You may report them to the FDA.

Adderall XR Side Effects

Medically reviewed by Drugs.com. Last updated on Nov 1, 2022.

Note: This document contains side effect information about amphetamine / dextroamphetamine. Some dosage forms listed on this page may not apply to the brand name Adderall XR.

Summary

Common side effects of Adderall XR include: headache, insomnia, weight loss, anorexia, and xerostomia. Other side effects include: nausea, and emotional lability. Continue reading for a comprehensive list of adverse effects.

Applies to amphetamine / dextroamphetamine: oral capsule extended release, oral tablet.

Warning

Oral route (Tablet)

Amphetamines have a high potential for abuse and administration for prolonged periods of time may lead to drug dependence. Misuse of amphetamines may cause sudden death and serious cardiovascular adverse reactions.

Oral route (Capsule, Extended Release)

CNS stimulants, including dextroamphetamine/amphetamine extended-release capsules, other amphetamine-containing products, and methylphenidate, have a high potential for abuse and dependence. Assess the risk of abuse prior to prescribing and monitor for signs of abuse and dependence while on therapy.

Serious side effects of Adderall XR

Along with its needed effects, amphetamine / dextroamphetamine may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

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Check with your doctor immediately if any of the following side effects occur while taking amphetamine / dextroamphetamine:

More common

  • Bladder pain
  • bloody or cloudy urine
  • difficult, burning, or painful urination
  • fast, pounding, or irregular heartbeat or pulse
  • frequent urge to urinate
  • lower back or side pain

Less common

  • Chills
  • cough
  • diarrhea
  • fever
  • general feeling of discomfort or illness
  • headache
  • hoarseness
  • joint pain
  • loss of appetite
  • muscle aches and pains
  • nausea
  • runny nose
  • shivering
  • sore throat
  • sweating
  • trouble sleeping
  • unusual tiredness or weakness
  • vomiting

Incidence not known

  • Blistering, peeling, or loosening of the skin
  • chest pain or discomfort
  • confusion
  • dark urine
  • difficulty breathing
  • difficulty with speaking
  • difficulty with swallowing
  • dizziness
  • double vision
  • faintness
  • inability to move the arms, legs, or facial muscles
  • inability to speak
  • itching, skin rash
  • large, hive-like swelling on the face, eyelids, lips, tongue, throat, hands, legs, feet, or genitals
  • loss of bladder control
  • muscle cramps or stiffness
  • muscle spasm or jerking of the arms and legs
  • pain or discomfort in the arms, jaw, back, or neck
  • red skin lesions, often with a purple center
  • red, irritated eyes
  • seeing, hearing, or feeling things that are not there
  • seizures
  • slow speech
  • sores, ulcers, or white spots in the mouth or on the lips
  • sudden loss of consciousness
  • swelling of the feet or lower legs
  • tightness in the chest
  • uncontrolled repeated movements (tics)
  • uncontrolled vocal outbursts
  • unusual tiredness or weakness

Other side effects of Adderall XR

Some side effects of amphetamine / dextroamphetamine may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects.

Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

More common

  • Anxiety
  • dry mouth
  • lack or loss of strength
  • stomach pain
  • weight loss

Incidence not known

  • Constipation
  • decreased interest in sexual intercourse
  • false or unusual sense of well-being
  • inability to have or keep an erection
  • loss in sexual ability, desire, drive, or performance
  • twitching, twisting, uncontrolled repetitive movements of the tongue, lips, face, arms, or legs

For Healthcare Professionals

Applies to amphetamine / dextroamphetamine: oral capsule extended release, oral tablet.

Metabolic

Very common (10% or more): Appetite loss (up to 36%), weight loss (up to 10%)

Frequency not reported: Anorexia [Ref]

Gastrointestinal

Very common (10% or more): Dry mouth (up to 35%), abdominal pain (up to 14%)

Common (1% to 10%): Nausea, vomiting, diarrhea, dyspepsia

Frequency not reported: Unpleasant taste, constipation, other GI disturbances [Ref]

Cardiovascular

Very common (10% or more): Transient blood pressure elevations (up to 35%)

Common (1% to 10%): Tachycardia, palpitation

Frequency not reported: Cardiomyopathy, myocardial infarction, Raynaud’s phenomenon [Ref]

Psychiatric

Very common (10% or more): Insomnia (up to 27%), nervousness (up to 13%)

Common (1% to 10%): Emotional lability, agitation, anxiety

Frequency not reported: Psychotic episodes, irritability, euphoria, dysphoria, restlessness, depression, aggression, anger, logorrhea, dermatillomania [Ref]

Nervous system

Very common (10% or more): Headache (up to 26%)

Common (1% to 10%): Somnolence, dizziness, twitching, speech disorder (e.g., stuttering, excessive speech)

Frequency not reported: Overstimulation, paresthesia/formication, dyskinesia, tremor, exacerbation of motor/phonic tics and Tourette’s syndrome [Ref]

Dermatologic

Common (1% to 10%): Photosensitivity reaction, sweating

Endocrine

Common (1% to 10%): Decreased libido, dysmenorrhea, impotence

Frequency not reported: Frequent or prolonged erections [Ref]

Genitourinary

Other

Common (1% to 10%): Fever, infection, accidental injury, asthenia/fatigue, tooth disorder (e.g., teeth clenching, tooth infection)

Frequency not reported: Sudden death, bruxism [Ref]

Respiratory

Hypersensitivity

Frequency not reported: Hypersensitivity reactions (e.g., angioedema, anaphylaxis) [Ref]

Ocular

Frequency not reported: Blurred vision, mydriasis [Ref]

Musculoskeletal

Postmarketing reports: Rhabdomyolysis [Ref]

Frequently asked questions

  • How long does Adderall last?
  • Which tablets should never be crushed?
  • How is Mydayis different from Adderall XR?
  • Is Adzenys XR-ODT the same as Adderall XR?
  • How do you get rid of Adderall tongue?
  • How long does Adderall withdrawal last?

More about Adderall XR (amphetamine / dextroamphetamine)

  • Check interactions
  • Compare alternatives
  • Pricing & coupons
  • Reviews (226)
  • Drug images
  • Dosage information
  • Patient tips
  • During pregnancy
  • Generic availability
  • Support group
  • Drug class: CNS stimulants
  • En español

Patient resources

  • Drug Information
  • Adderall XR (Advanced Reading)

Other brands

Professional resources

Other formulations

Related treatment guides

References

1. “Product Information. Adderall (amphetamine-dextroamphetamine).” Shire Richwood Pharmaceutical Company Inc (2001):

2. “Product Information. Adderall XR (amphetamine-dextroamphetamine).” Shire Richwood Pharmaceutical Company Inc (2001):

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

Some side effects may not be reported. You may report them to the FDA.

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Alex Koliada, PhD

Alex Koliada, PhD

Alex Koliada, PhD, is a well-known doctor. He is famous for his studies of ageing, genetics and other medical conditions. He works at the Institute of Food Biotechnology and Genomics NAS of Ukraine. His scientific researches are printed by the most reputable international magazines. Some of his works are: Differences in the gut Firmicutes to Bacteroidetes ratio across age groups in healthy Ukrainian population [BiomedCentral.com]; Mating status affects Drosophila lifespan, metabolism and antioxidant system [Science Direct]; Anise Hyssop Agastache foeniculum Increases Lifespan, Stress Resistance, and Metabolism by Affecting Free Radical Processes in Drosophila [Frontiersin].
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